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Efficacy of Persian medicine herbal formulations (capsules and decoction) compared to standard care in patients with COVID-19, a multicenter open-labeled, randomized, controlled clinical trial.

Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran. Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran. Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran. Department of Infectious Diseases, Pakdasht Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran. Faculty of Medicine, University of Helsinki, Helsinki, Finland. Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran. Evidence Based Integrative Medicine Research Center, Kashan University of Medical Sciences, Kashan, Iran. Department of Internal Medicine, School of Medicine, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Social Determinants of Health Research Center, Kashan University of Medical Sciences, Kashan, Iran. Department of Infectious Disease, Isabn-e-Maryam Hospital, Isfahan, Iran. Department of Infectious Disease, School of Medicine, Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran. Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. Department of Persian Medicine, School of Persian Medicine, Babol University of Medical Sciences, Babol, Iran. Department of Persian Medicine, School of Persian Medicine, Qom University of Medical Sciences, Qom, Iran. Department of Persian Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Department of Persian Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran. Research Institute for Islamic and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran. Department of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Niak Pharmaceutical Company, Gorgan, Iran. Department of Infectious Disease, School of Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Phytotherapy research : PTR. 2021;(11):6295-6309
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Abstract

Persian medicine has recommended clinical experiences and proper herbal remedies for prevention and treatment of microbial infections and respiratory diseases. An open-label, randomized, controlled, multicenter trial was conducted at five hospitals in Tehran and Isfahan provinces of Iran on 358 hospitalized adult patients. A total of 174 patients received standard care and 184 received herbal remedies (polyherbal decoction every 8 hr and two herbal capsules every 12 hr) plus standard care for 7 days. The primary clinical endpoint was the duration of hospital stay, and secondary outcomes were clinical improvement of symptoms based on self-assessment questionnaire. Results demonstrated that these natural decoction and capsules treatment plus routine care significantly decreased duration of hospital dyspnea (3.291 day vs. 6.468 days), accelerated clinical improvement, and decreased symptoms such as dry cough, dyspnea, muscle pain, headache, fatigue, anorexia, chills, runny nose, sputum cough, and vertigo in the treatment group compared with standard-care group. Significant effects of these polyherbal formulations on improving the symptoms of COVID-19 could be incredibly promising for managing this pandemic with acceptable tolerability.

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